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Opioids and acute headache
Although opioids are commonly used for the emergency treatment of headache (Vinson, 2002),
they cannot be recommended for use on a regular basis because of the risk of dependency
and other opioid‐related adverse effects. The Australian Association of Neurologists
recommended that opioids should not be used for migraine unless the patient is unresponsive
to all other measures or where the use of ergot agents and triptans is contraindicated (Lance et
al, 1997). Pethidine in particular should be avoided in the treatment of headache, due to
evidence of poor efficacy compared with other migraine treatments (Friedman et al, 2008
Level I) and a higher risk of opioid dependency.
Key messages
Tension‐type headache
1. Acupuncture is effective in the treatment of tension‐type heachache (N) (Level I [Cochrane
Review]).
2. The addition of caffeine to aspirin or paracetamol improves analgesia in the treatment of
episodic tension‐type heachache (U) (Level I).
3. Simple analgesics such as aspirin, paracetamol or NSAIDs, either alone or in combination,
are effective in the treatment of episodic tension‐type heachache (U) (Level II).
Migraine
4. Triptans are effective in the treatment of severe migraine (U) (Level I).
5. Aspirin‐metoclopramide is effective in the treatment of mild‐to‐moderate migraine (U)
(Level I).
6. Parenteral metoclopramide is effective in the treatment of migraine (U) (Level I).
7. Over‐the‐counter medications, including combined paracetamol‐aspirin‐caffeine
preparations, are effective in the treatment of migraine with mild‐to‐moderate symptoms
and disability (N) (Level I).
8. Effervescent aspirin, ibuprofen or dipyrone are effective in the treatment of migraine (N)
(Level I).
9. In children or adolescents with migraine, ibuprofen or intranasal sumatriptan (over 12 CHAPTER 9
years of age) are effective treatments (N) (Level I).
10. Pethidine is less effective than most other migraine treatments and should not be used (N)
(Level I).
11. Parenteral prochlorperazine, chlorpromazine or droperidol are effective in the treatment
of migraine, especially in the emergency department (N) (Level II).
12. Paracetamol is effective in the treatment of mild‐to‐moderate migraine (U) (Level II).
13. A ‘stratified care strategy’ is effective in treating migraine (U) (Level II).
Cluster headache
14. Parenteral triptans (sumatriptan or zolmitriptan) (S) or oxygen therapy (U), are effective
treatments for cluster headache attacks (Level II).
Acute pain management: scientific evidence 271

