Page 129 WHO - Guidelines on the pharmacological treatment of persisting pain in children with medical illness

Hahn TW et al. Pharmacokinetics of rectal paracetamol after repeated dosing in children. British Journal
of Anaesthesia, 2000, 85:512–519.

Howell TK, Patel D. Plasma paracetamol concentrations after different doses of rectal paracetamol in
older children: a comparison of 1 g vs. 40 mg.kg-1. Anaesthesia, 2003, 58:69–73.

Montgomery CJ et al. Plasma concentrations after high-dose (45 mg.kg-1) rectal acetaminophen in
children. Canadian Journal of Anesthesia, 1995, 42:982–986.

PArAcetAmol versus ibuProfen

Bertin L et al. Randomized, double-blind, multicenter, controlled trial of ibuprofen versus
acetaminophen (paracetamol) and placebo for treatment of symptoms of tonsillitis and pharyngitis in
children. Journal of Pediatrics, 1991, 119:811–814.

Kelley MT et al. Pharmacokinetics and pharmacodynamics of ibuprofen isomers and acetaminophen in
febrile children. Clinical Pharmacology & Therapeutics, 1992, 52:181–189.

Lesko SM, Mitchell AA. An assessment of the safety of pediatric ibuprofen. A practitioner-based
randomized clinical trial. Journal of the American Medical Association, 1995, 273:929–933.

Perrott DA et al. Efficacy and safety of acetaminophen vs ibuprofen for treating children’s pain or fever:
a meta-analysis. Archives of Pediatrics & Adolescent Medicine, 2004, 158:521–526.

trAmAdol
Allegaert K et al. Tramadol disposition in the very young: an attempt to assess in vivo cytochrome P-450
2D6 activity. British Journal of Anaesthesia, 2005, 95:231–239.

Bozkurt P. Review article: use of tramadol in children. Pediatric Anesthesia, 2005, 15:1041–1047
doi:10.1111

Brown, SC, Stinson J. Treatment of pediatric chronic pain with tramadol hydrochloride: siblings with
Ehlers-Danlos syndrome – Hypermobility type (case report). Pain Research & Management, 2004,
9:209–211.

Garrido MJ et al. Population pharmacokinetic/pharmacodynamic modelling of the analgesic effects of
tramadol in pediatrics. Pharmaceutical Research, 2006, 23:2014–2023.

Kamel C. Tramadol en analgesia pédiatrica. Revista Iberoamerican del Dolor, 2008, 3:36–45.

Rose JB et al. Oral tramadol for the treatment of pain of 7–30 days’ duration in children. Anesthesia &
Analgesia, 2003, 96:78–81.

codeine
Tremlett M, Anderson BJ, Wolf A. Pro-con debate: is codeine a drug that still has a useful role in
pediatric practice? Paediatric Anaesthesia, 2010, 20:183–194.

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