Page 130 WHO - Guidelines on the pharmacological treatment of persisting pain in children with medical illness

Williams DG, Hatch DJ, Howard RF. Codeine phosphate in paediatric medicine. British Journal of
Anaesthesia, 2001, 86:413–421.
A1
ibuProfen versus codeine + PArAcetAmol

Drendel AL et al. A randomized clinical trial of ibuprofen versus acetaminophen with codeine for acute
pediatric arm fracture pain. Annals of Emergency Medicine, 2009, 54:553–560.

morPhine
A2
Anderson BJ et al. The dose-effect relationship for morphine and vomiting after day-stay tonsillectomy in
children. Anaesthesia and Intensive Care, 2000, 28:155–160.

Bhandari V et al. Morphine administration and short-term pulmonary outcomes among ventilated
preterm infants. Pediatrics, 2005, 116:352–359.

Bouwmeester NJ et al. Developmental pharmacokinetics of morphine and its metabolites in neonates,
infants and young children. British Journal of Anaesthesia, 2004, 92:208–217. A3

Koren G et al. Postoperative morphine infusion in newborn infants: assessment of disposition
characteristics and safety. Journal of Pediatrics, 1985, 107:963–967.

McNicol R. Postoperative analgesia in children using continuous s.c. morphine. British Journal of
Anaesthesia, 1993, 71:752–756.
A4 A4
Saarenmaa E et al. Morphine clearance and effects in newborn infants in relation to gestational age.
Clinical Pharmacology and Therapeutics, 2000, 68:160–166.

Zernikow B, Lindena G. Long-acting morphine for pain control in paediatric oncology. Medical and
Pediatric Oncology, 2001, 36:451–458.

fentAnyl A5

Saarenmaa E, Neuvonen PJ, Fellman V. Gestational age and birth weight effects on plasma clearance of
fentanyl in newborn infants. Journal of Pediatrics, 2000, 136:767–770.

Singleton MA, Rosen JI, Fisher DM. Plasma concentrations of fentanyl in infants, children and adults.
Canadian Journal of Anaesthesia, 1987, 34:152–155.
A6
Yaster M. The dose response of fentanyl in neonatal anesthesia. Anesthesiology, 1987, 66:433–435.

fentAnyl versus morPhine

Saarenmaa E et al. Advantages of fentanyl over morphine in analgesia for ventilated newborn infants
after birth: a randomized trial. Journal of Pediatrics, 1999, 134:144–150.
A7
AdjuvAnts
Saarenmaa E et al. Ketamine for procedural pain relief in newborn infants. Archives of Disease in
Childhood. Fetal and Neonatal Edition, 2001, 85:F53–F56.

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