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administração escolhida permitiu usar peque- ical study. Pain. 1999;80(3):463-70.
nas, mas ao mesmo tempo eficazes, doses de 16. Allen SJ, Dawbarn D. Clinical relevance of the neurotrophins and
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TrkA-Ig2, comparativamente com que havia sido 17. Levi-Montalcini R. Nerve Growth Factor. Science. 1975;187(4172):113.
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descrito . O NGF pode contribuir para a disfun- 18. Albers KM, Wright DE, Davis BM. Overexpression of nerve growth
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nilloid 1 (TRPV1) ou reduzindo as correntes de 20. Pincelli C, Marconi A. Autocrine nerve growth factor in human kera-
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+
K do tipo A , seja por induzir a expressão re- 21. Stanzel RD, Lourenssen S, Blennerhassett MG. Inflammation causes
ceptores e péptidos envolvidos na nocicepção, expression of NGF in epithelial cells of the rat colon. Exp Neurol.
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como a substância P e péptido relacionado com 22. Levi-Montalcini R. The nerve growth factor 35 years later. Science.
o gene da calcitonina (CGRP) 14,77 . 1987;237(4819):1154-62.
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on antagonism of NGF. Trends in Pharmacol Sci. 2006;27(2):85-91.
indicam que o NGF é um dos principais media- 24. Lowe EM, Anand P, Terenghi G, Williams-Chestnut RE, Sinicropi DV,
dores que conduzem à dor referida e hiperacti- Osborne JL. Increased nerve growth factor levels in the urinary
vidade vesical, que resultam de, e acompanham, bladder of women with idiopathic sensory urgency and interstitial
a cistite crónica inflamação crónica da bexiga. cystitis. Br J Urol. 1997;79(4):572-7.
Dado que a sequestração de NGF reduziu a dor 25. Jaggar SI, Scott HF, Rice AC. Inflammation of the rat urinary bladder
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xiga, é provável que a manipulação dos níveis 26. Woolf CJ, Safieh-Garabedian B, Ma QP, Crilly P, Winter J. Nerve
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Este trabalho foi financiado pelo projecto 7. 28. Okragly AJ, Niles AL, Saban R, et al. Elevated tryptase, nerve growth
o
Programa Quadro Europeu INComb (FP7 HEALTH factor, neurotrophin-3 and glial cell line-derived neurotrophic factor
levels in the urine of interstitial cystitis and bladder cancer patients.
project no 223234) e pela Fundação para a Ci- J Urol. 1999;161(6):438-41.
ência e Tecnologia (bolsa de doutoramento 29. Pinto R, Lopes T, Frias B, et al. Trigonal injection of botulinum toxin
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