Page 421 Acute Pain Management

Lerman J, Nolan J, Eyres R et al (2003) Efficacy, safety, and pharmacokinetics of levobupivacaine with and
without fentanyl after continuous epidural infusion in children: a multicenter trial. Anesthesiology 99(5):
1166–74.
Lesko SM & Mitchell AA (1995) An assessment of the safety of pediatric ibuprofen. A practitioner‐based
randomized clinical trial. JAMA 273(12): 929–33.
Lesko SM & Mitchell AA (1999) The safety of acetaminophen and ibuprofen among children younger than
two years old. Pediatrics 104(4): e39.
Lesko SM, Louik C, Vezina RM et al (2002) Asthma morbidity after the short‐term use of ibuprofen in
children. Pediatrics 109(2): E20.
Leyvi G, Taylor DG, Reith E et al (2005) Caudal anesthesia in pediatric cardiac surgery: does it affect
outcome? J Cardiothorac Vasc Anesth 19(6): 734–8.
Lin YC, Sentivany‐Collins SK, Peterson KL et al (1999) Outcomes after single injection caudal epidural
versus continuous infusion epidural via caudal approach for postoperative analgesia in infants and
children undergoing patent ductus arteriosus ligation. Paediatr Anaesth 9(2): 139–43.
Lindh V, Wiklund U, Blomquist HK et al (2003) EMLA cream and oral glucose for immunization pain in
3‐month‐old infants. Pain 104(1‐2): 381–8.
Liossi C, White P & Hatira P (2006) Randomized clinical trial of local anesthetic versus a combination of
local anesthetic with self‐hypnosis in the management of pediatric procedure‐related pain. Health
Psychol 25(3): 307–15.
Liossi C, White P, Franck L et al (2007) Parental pain expectancy as a mediator between child expected
and experienced procedure‐related pain intensity during painful medical procedures. Clin J Pain 23(5):
392–9.
Liossi C, White P & Hatira P (2009) A randomized clinical trial of a brief hypnosis intervention to control
venepuncture‐related pain of paediatric cancer patients. Pain 142(3): 255–63.
Litalien C & Jacqz‐Aigrain E (2001) Risks and benefits of nonsteroidal anti‐inflammatory drugs in children:
a comparison with paracetamol. Paediatr Drugs 3(11): 817–58.
Ljungman G, Kreuger A, Gordh T et al (1996) Treatment of pain in pediatric oncology: a Swedish
nationwide survey. Pain 68(2‐3): 385–94.
Ljungman G, Gordh T, Sorensen S et al (1999) Pain in paediatric oncology: interviews with children,
adolescents and their parents. Acta Paediatr 88(6): 623–30.
Ljungman G, Gordh T, Sorensen S et al (2000) Pain variations during cancer treatment in children: a
descriptive survey. Pediatr Hematol Oncol 17(3): 211–21.
Llewellyn N & Moriarty A (2007) The national pediatric epidural audit. Paediatr Anaesth 17(6): 520–33.
Locatelli BG, Frawley G, Spotti A et al (2008) Analgesic effectiveness of caudal levobupivacaine and
ketamine. Br J Anaesth 100(5): 701–6.
Lovstad RZ & Stoen R (2001) Postoperative epidural analgesia in children after major orthopaedic
surgery. A randomised study of the effect on PONV of two anaesthetic techniques: low and high dose i.v. CHAPTER 10
fentanyl and epidural infusions with and without fentanyl. Acta Anaesthesiol Scand 45(4): 482–8.
Ludot H, Tharin JY, Belouadah M et al (2008) Successful resuscitation after ropivacaine and lidocaine‐
induced ventricular arrhythmia following posterior lumbar plexus block in a child. Anesth Analg 106(5):
1572–4.
Luhmann JD, Kennedy RM, Porter FL et al (2001) A randomized clinical trial of continuous‐flow nitrous
oxide and midazolam for sedation of young children during laceration repair. Ann Emerg Med 37(1):
20–7.
Luhmann JD, Schootman M, Luhmann SJ et al (2006) A randomized comparison of nitrous oxide plus
hematoma block versus ketamine plus midazolam for emergency department forearm fracture reduction
in children. Pediatrics 118(4): e1078–86.
Lynn A, Nespeca MK, Bratton SL et al (1998) Clearance of morphine in postoperative infants during
intravenous infusion: the influence of age and surgery. Anesth Analg 86(5): 958–63.
Lynn AM, Nespeca MK, Bratton SL et al (2000) Intravenous morphine in postoperative infants:
intermittent bolus dosing versus targeted continuous infusions. Pain 88(1): 89–95.

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