Page 16

I. Tavares, et al.: Perspectivas de Manipulação do Sistema Endógeno de Controlo da DOR: o Bolbo Raquidiano Ventrolateral
Cravo SL, Morrison SF, Reis DJ. Differentiation of two cardiovascular Maixner W, Touw KB, Brody MJ, Gebhart GF, Long JP. Factors influencing
regions within caudal ventrolateral medulla. American J Physiol the altered pain perception in the spontaneously hypertensive rat.
1991;261:985-94. Brain Res 1982;237:137-45.
Ditto B, Edwards MC, Miller S, D’Antono B, Blum S. The effects of sodium Melzak R, Wall PD. Pain mechanisms: a new theory. Science 1965;150:
loading on blood pressure and pain responses to the cold pressor 971-9.
test. J Psychom Res 1993;37:771-80. Menétrey D, De Pommery J, Besson JM. Electrophysiological characteris-
Eilam R, Malach R, Bergmann F, Segal M. Hypertension induced by tics of lumbar spinal neurons backfired from the lateral reticular
hypothalamic transplantation from genetically hypertensive to nor- nucleus in the rat. J Neurophysiol 1984;52:595-609.
motensive rats. J Neurosci 1991;11:401-11. Randich A. Sinoaortic baroreceptor reflex arc modulation of nociception in
Foong FW, Duggan AW. Brain-stem areas tonically inhibiting dorsal horn spontaneously hypertensive and normotensive rats. Physiology and
neurones: studies with microinjection of the GABA analogue pipe- Psychology 1982;10:267-72.
ridine-4-sulphonic acid. Pain 1986;27:361-71. Randich A, Maixner W. Interactions between cardiovascular and pain
Hall JG, Duggan AW, Morton CR, Johnson SM. The location of brainstem regulatory systems. Neurosci Biobehav Rev 1984;8:343-67.
neurones tonically inhibiting dorsal horn neurones of the cat. Brain Randich A, Robertson JD. Spinal nociceptive transmission in the sponta-
Res 1982;244:215-22. neously hypertensive and Wistar-Kyoto normotensive rat. Pain
Gebhart GF, Ossipov MH. Characterization of inhibition of the spinal 1994;58:169-83.
nociceptive tail-flick reflex in the rat from the medullary lateral Satoh M, Akaike A, Nakazawa T, Takagi H. Evidence for involvement of
reticular nucleus. J Neurosci 1986;6:701-13. separate mechanisms in the production of analgesia by electrical
Ghione S, Rosa C, Mezzasalma L, Panattoni E. Arterial hypertension is stimulation of the nucleus reticularis paragigantocellularis and nu-
associated by hypoalgesia in humans. Hypertension cleus raphe magnus in the rat. Brain Res 1980;194:525-9.
1988;12:491-7. Simpson BA. Spinal cord and brain stimulation. Em: Wall PD, Melzak R
Ghione S, Rosa C, Panattoni E, Nutti M, Mezzasalma L, Guiliano G. (eds). Textbook of pain. Edinburgh: Churchill Livingstone
Comparisons of sensory and pain threshold in tooth pulp stimula- 1999:1353-81.
tion in normotensive man and essential hypertension. J Hyperten- Shapiro AP. An experimental study of comparative responses of blood
sion 1985;3:113-15. pressure to different noxious stimuli. J Chronic Disease 1961;13:
Gogas KR, Presley RW, Levine JD, Basbaum AI. The antinociceptive 293-311.
action of supraspinal opioids results from an increase in descen- Tavares I, Lima D, Coimbra A. Neurons in the superficial dorsal horn of the
ding inhibitory control: correlation of nociceptive behavior and c-fos rat spinal cord projecting to the medullary reticular formation
expression. Neuroscience 1991;41:617-28. express c-fos after noxious stimulation of the skin. Brain Res
Janss AJ, Gebhart GF. Spinal monoaminergic receptors mediate the 1993;623:278-82.
antinociception produced by glutamate in the medullary lateral Tavares I, Lima D. Descending projections from the caudal medulla
reticular nucleus. J Neurosci 1987;7:2862-73. oblongata to the superficial or deep dorsal horn of the rat spinal
Janss AJ, Gebhart GF. Quantitative characterization and spinal pathway cord. Exp Brain Res 1994;99:455-63.
mediating inhibition of spinal nociceptive transmission from the Tavares I, Albino-Teixeira A, Lima D. Hypertension inhibits noxious evoked
lateral reticular nucleus in the rat. J Neurophysiol 1988;59:226-47. c-fos expression in the rat spinal cord. Neuroreport 1995;6:1664-8.
Jensen TS, Yaksh TL. Spinal monoamine and opiate systems partly Tavares I, Lima D, Coimbra A. The ventrolateral medulla of the rat is
mediate the antinociceptive effects produced by glutamate at connected with the spinal cord dorsal horn by an indirect descen-
brainstem sites. Brain Res 1984;321:287-97. ding pathway relayed in the A noradrenergic cell group. J Comp
5
Jones SL. Descending control of nociception. Em: Gildenberg P (ed). The Neurol 1996;374:84-95.
initial processing of pain and its descending control: spinal and Tavares I, Lima D, Coimbra A. The pontine A noradrenergic cells which
5
trigeminal systems. Basel: Karger 1992;203-95. project to the spinal cord dorsal horn are reciprocally connected
Liebeskind JC, Guilbaud G, Besson JM, Oliveras J. Analgesia from with the caudal ventrolateral medulla in the rat. Europ J Neurosci
electrical stimulation of the periaqueductal gray matter in the cat: 1997;9:2452-61.
behavioral observations and inhibitory effects on spinal interneu- Tavares I, Almeida A, Albino-Teixeira A, Lima D. Lesions of the caudal
rons. Brain Res 1973;50:441-6. ventrolateral medulla block the hypertension-induced inhibition of
Lima D, Coimbra A. Neurons in the substantia gelatinosa rolandi (lamina noxious-evoked c-fos expression in the rat spinal cord. Europ J
II) project to the caudal ventrolateral reticular formation of the Pain 1997;1:149-60.
medulla oblongata in the rat. Neurosci Lett 1991;132:16-8. Thurston CL, Randich A. Acute increases in arterial blood pressure
Lima D, Mendes-Ribeiro JA, Coimbra A. The spino-latero-reticular system produced by occlusion of the abdominal aorta induces antinoci-
of the rat: projections from the superficial dorsal horn and structural ception: peripheral and central substrates. Brain Res 1990;519:12-
characterization of marginal neurons involved. Neuroscience 22.
1991;45:137-52. Zamir N, Maixner W. The relationship between cardiovascular and pain
Maixner W. Autonomic and somatosensory interactions: physiological regulatory systems. Ann NY Acad Sci 1986;467:371-89.
and pathophysiological implications. Proc Finn Dental Soc Zamir N, Simantov R, Segal M. Pain sensitivity and opioid activity in
1989;85:395-407. genetically hypertensive rats. Brain Res 1980;184:299-310.
Maixner W. Interactions between cardiovascular and pain modulatory Zamir N, Segal M. Hypertension-induced analgesia: changes in pain
systems: physiological and pathophysiological implications. J Car- sensitivity in experimental hypertensive rats. Brain Res 1979;
diovasc Electrophysiol 1991;2:3-12. 160:170-3.

DOR

15