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C.D. Cruz, et al.: A Estimulação Mecânica de Articulações Monoartríticas Induz Fosforilação das ERKs 1 e 2 na Medula Espinhal
Butler SH, Weil-Fugazza J. The foot-bend procedure as test of nociception Karim F, Wang CC, Gereau IV RW. Metabotropic glutamate receptor sub-
for chronic studies in a model of monoarthritis in the rat. Pharmacol types 1 and 5 are activators of extracellular signal-regulated kinase
Commun 1994;4:327-34. signaling required for inflammatory pain in mice. J Neurosci
Castro AR, Bowery N, Castro-Lopes JM. Baclofen and midazolam alter c- 2001;21(11):3771-9.
fos induction by peripheral noxious or innocuous stimulation in the Kerr BJ, Bradbury EJ, Bennett DLH, et al. Brain-derived neurotrophic fac-
spinal cord of normal and monoarthritic rats. Neuropharmacology tor modulates nociceptive sensory inputs and NMDA-evoked res-
1999;38:1775-88. ponses in the rat spinal cord. J Neurosci 1999;19:5138-48.
Castro-Lopes JM, Tavares I, Tölle TR, Coito A, Coimbra A. Increase in GA- Lewin MR, Walters ET. Cyclic GMP pathway is critical for inducing long-term
BAergic cells and GABA levels in the spinal cord in unilateral inflam- sensitization of nociceptive sensory neurons. Nat Neurosci
mation of the hindlimb in the rat. Eur J Neurosci 1992;4:296-301. 1999;2(1):18-23.
Coghill RC, Price DD, Hayes RL, Mayer DJ. Spatial distribution of noci- Neto FL, Schadrack J, Ableitner A, et al. Supraspinal metabolic activity
ceptive processing in the rat spinal cord. J Neurophysiol 1991; changes in the rat during adjuvant monoarthritis. Neuroscience
65:133-40. 1999;94(2):607-21.
Danziger N, Weil-Figazza J, Le Bars D, Bouhassira D. Alteration of des- Pezet S, Onteniente B, Grannec G, Calvino B. Chronic pain is associated
cending modulation of nociception during the course of monoarthri- with increased TrkA immunoreactivity in spinoreticular neurons. J
tis in the rat. J Neurosci 1999;19(6):2394-400. Neurosci 1999;19(13):5482-92.
Danziger N, Weil-Figazza J, Le Bars D, Bouhassira D. Stage-depen- Pezet S, Onteniente B, Jullien J, et al. Differential regulation of NGF recep-
dent changes in the modulation of spinal nociceptive neuronal tors in primary sensory neurons by adjuvant-induced arthritis in the
activity during the course of inflammation. Europ J Neurosci rat. Pain 2000;90:113-25.
2001;13:230-40. Pezet S, Malcangio M, Lever IJ, et al. Noxious stimulation induces Trk re-
Derkinderen P, Enslen H, Girault JA. The ERKs/MAP-kinases cascade in ceptor and downstream ERKs phosphorylation in spinal dorsal horn.
the nervous system. Neuroreport 1999;10(5):24-34. Mol Cell Neurosci 2002;21:684-95.
Dray A, Urban L, Dickenson A. Pharmacology of chronic pain. TIPS Porro CA, Cavazzuti M. Functional imaging studies of the pain system in
1994;15:190-7. man and animals. Prog Brain Res 1996;110:47-62.
Doubell TP, Mannion RJ, Woolf CJ. The dorsal horn: state-dependent sen- Schadrack J, Castro-Lopes JM, Avelino A, Zieglgansberger W, Tolle TR. Mo-
sory processing, plasticity and the generation of pain. Em: Wall PD, dulated expression of c-Fos in the spinal cord following noxious thermal
a
Melzack R, editores. Textbook of pain. 4. ed. Londres: Churchill stimulation of monoarthritic animals. J Neurosci Res 1998;53:203-13.
Livingstone; 1999. p. 165-81. Schadrack J, Neto FL, Ableitner A, et al. Metabolic activity changes in the
Galán A, López-García JA, Cervero F, Laird JM. Phosphorylation of spinal rat spinal cord during adjuvant monoarthritis. Neuroscience 1999;
extracellular-signalling regulated kinase-1 and -2 by intraplantar ca- 94(2):595-605.
rrageenan in rodents. Neurosci Lett 2002;322(1):37-40. Sluka K. Phosphorylation of the cAMP transduction cascade contributes to
Galán A, Cervero F, Laird JM. Extracellular signalling-regulated kinase-1 the mechanical hyperalgesia and allodynia induced by intradermal
and -2 (ERK 1/2) mediate referred hyperalgesia in a murine model injection of capsaicin. Br J Pharmacol 1997;122:1165-73.
of visceral pain. Brain Res Mol Brain Res 2003;116:126-34. Sluka K, Willis WD. Increased spinal release of excitatory amino acids fo-
Grewal SS, York RD, Stork PJS. Extracellular-signal-regulated kinase sig- llowing intradermal injection of capsaicin is reduced by a protein
nalling in neurons. Curr Opin Neurobiol 1999;9:544-53. kinase G inhibitor. Brain Res 1998;798:281-6.
Groth R, Aanonsen L. Spinal brain-derived neurotrophic factor (BDNF) Sweatt JD. The neuronal MAP kinase cascade: a biochemical signal inte-
produces hyperalgesia in normal mice while antisense directed gration system subserving synaptic plasticity and memory. J Neuro-
against either BDNF or trkB, prevent inflammation-induced hyperal- chem 2001;76:1-10.
gesia. Pain 2002;100(1-2):171-81. Tölle TR, Schadrack J, Castro-Lopes JM, Zieglgänsberger W. Immediate
Ji RR, Baba H, Brenner GJ, Woolf CJ. Nociceptive-specific phosphorylation early genes in nociception. Em: Tölle TR, Schadrack J, Zieglgäns-
in spinal neurons contributes to pain hypersensitivity. Nat Neurosci berger W, editores. Immediate early genes in the Central Nervous
1999;2(12):1114-9. System. Berlim: Springer; 1995. p. 51-77.
Ji RR, Woolf CJ. Neuronal plasticity and signal transduction in nociceptive Willis WD, Westlund KN. Neuroanatomy of the pain system and of the
neurons: implications for the initiation and maintenance of patholo- pathways that modulate pain. J Clin Neurophysiol 1997;14:2-31.
gical pain. Neurobiol Dis 2000;8:1-10. Willis WD, Westlund KN, Carlton SM. Pain. Em: Paxinos G, editor. The rat ner-
a
Ji RR, Befort K, Brenner GJ, Woolf CJ. ERK MAP kinase activation in su- vous system. 2. ed. San Diego: Academic Press; 1995. p. 725-50.
perficial spinal cord neurons induces prodynorphin and NK-1 upre- Woolf CJ, Slater MW. Increasing the gain in pain. Science 2000;288:1765-8.
gulation and contributes to persistent inflammatory pain hypersen- Zimmermann M. Ethical guidelines for investigations of experimental pain
sitivity. J Neurosci 2002;22:478-85. in conscious animals. Pain 1983;16:109-10.
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