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fisiopatogenia impunha-se a investigação de 14. Russell MB, Olesen J. Increased familial risk and evidence of gene-
tic factor in migraine. BMJ 311, 1993:541-4.
eventuais mutações genéticas nestes neurotrans- 15. Peroutka SJ, Howell TA. The genetic analysis of migraine: Clinical
missores. Dos estudos já efectuados foram exclu- database requirements. In: Rose F, ed Leeds Castle Migraine Wor-
ídos, até à data, os genes reguladores dos se- kshop. Elsevier Science 1995.
guintes receptores: 5HT2A; 5-HT2B; DRD2 32,33 . 16. Lemos C, Castro M, Barros J, et al. Familial aggregation of forms of
migraine in a group of Portuguese families [abstract] (em prensa)*.
17. *Coelho J, Alonso I, Barros J,et al. Caracterização molecular do
Conclusão gene CACNA1A em famílias e doentes com enxaqueca. Resumos
a
da 7. Reunião da Sociedade Portuguesa de Neurociências, 2001;
O estudo genético da enxaqueca teve um gran- (P16)56*.
de incremento na última década do século XX e 18. *Castro MJ, Pinto M, Mendonça T, et al. Estudo genético da enxaque-
ca: aspectos clínicos e moleculares. Sinapse 2004;4(2):32-6.
prossegue em diversos laboratórios, sobretudo, na 19. Ziegler DK, Hur YM, Bouchard TJ Jr, Hassanein RS, Barter Migraine in
Europa e na América do Norte, pelo que se espe- twins raised together and apart. Headache 1998;38(6):417-22.
ra que os múltiplos genes provavelmente envol- 20. Merikangas KR. Genetics of migraine and other headaches. Current
vidos na enxaqueca venham a ser identificados Opinion in Neurology 1996;9:202-6.
nas primeiras décadas do século actual. 21. Honkasalo ML, Kaprio J, Winter T, Heikkila K, Sillanpaa M, Kosken-
vuo M. Migraine and concomitant symptoms among 8167 adult twin
pairs. Headache 1995;35(2):70-8.
Bibliografia 22. Larsson B, Bille B., Pederssen NL. Genetic influence in headaches:
a Swedish twin study. Headache 1995;35(9):513-9.
1. Goadsby PJ. Pathopfysiology of headache. Em: Wolf’s Headache 23. Svensson DA, Larsson B, Walderlind E, Pedersen NL. Shared rearing
and Other head pain. Edited by Stephen D. Silberstein, Richard B. environment in migraine: results from twins reared apart and twins
a
Lipton & Donald J. Dalessio. 7. ed. Nova Iorque: Oxford University reared together. Headahe 2003 Mar;43 (3):235-44.
Press, inc.; 2001. p.57-72. 24. Mulder EJ, Van Baal C, Gaist D, et al. Genetic and environmental
2. Russell MB, Olesem J. The genetics of migraine without aura and influences on migraine: a twin study across six countries. Twin Res
migraine with aura. Cephalalgia 1993;13(4):245-8. 2003;6:422-31.
3. Liveing E. On megrim, sick-headache, and some allied disorders. 25. Joutel A, Bousser MG, Biousse V, et al. A gene for familial hemiple-
Londres: J and A Churchill; 1873. gic migraine maps to chromosome 19. Nat Genet 1993;5:40-5.
4. Ad Hoc Committee on Classification of Headache. Classification of 26. Ophoff RA, Terwindt GM, Vergouwe MN, et al. Familial hemiplegic
Headache. JAMA 1962;179:717-8. migraine and episodic ataxia type-2 are caused by mutations in the
5. World Federation of Neurology: Definition of Migraine. Em: Back- Ca2+ channel gene CACNL1A4. Cell 1996;87:543-52.
ground tp Migraine. Third Migraine symposium. Londres: Heineman; 27. Ducros A, Joutel A, Vahedi K, et al. Mapping of a second locus for
1970. p. 181-2. familial hemiplegic migraine to 1q21-q23 and evidence of further
6. Russell MB, Olesen J. The genetics of migraine without aura and heterogeneity. Ann Neurol 1997;42:885-90.
migraine with aura. Cephalalgia 1993;13(4):245-8. 28. Gardner K, et al. New locus for Hemiplegic Migraine Maps to chro-
7. Haan J,Terwindt GW, Ferrari MD. Genetics of migraine. Neurol Clin mosome 1q31. Neurology 1997;49:650-6.
1997;15:43-60. 29. Ducros A, Denier C, Joutel A, et al. The clinical spectrum of familial
8. Ferrari MD, Russell MB. Genetics of Migraine. Em: Olesen J, Tfelt- hemiplegic migraine associated with mutations in a neuronal calcium
a
Hansen P, Welch KMA. The Headaches, 2. ed. Nova Iorque: Raven channel. N Engl J Med 2001;345(1):17-24.
Press; 1999. Ch. 30. p. 241-54. 30. Tournier-Lasserve E. et al. CADASIL maps to chromossome 19q12.
9. Mochi M, et al.Testing models for genetic determination in Migraine. Nat Genet 1993;3:256-9.
Cephalalgia 1993;13:389-94. 31. Ptácek LJ. Channelopathies: Ion Channel Disorders of Muscle as a
10. International Headache Society Classification Subcommittee. Inter- Paradigma for paroxysmal Disorders of the Nervous System. Neu-
a
national classification of headache disorders. 2. ed. Cephalalgia romuscular Disorders 1997;7:250-5.
2004;24(suppl 1):1-160. 32. Terwindt GM et al. The Quest for Migraine Genes. Current Opinion
11. Ulrich V, Gervil M, Fenger K, Olesen J, Russell MB. The prevalence of Neurology 1997;10(3):221-5.
and characteristics of migraine in twins from the general population. 33. Ferrari M. From Genetics to Prophylaxis. Cephalalgia 1997;17(suppl
Headache 1999;39(3):173-80. 17):2-4.
12. Hovatta I, Kallela M, Farkkila M, et al. Familial Migraine. Exclusion
of the susceptibility gene from the reported locus of familial hemi- *Trabalhos efectuados no âmbito do Projecto de Investigação «Estu-
plegic migraine on 19p. Genomics 1994;23:707-9. do Genético da Enxaqueca» coordenado por JM Pereira Monteiro do
13. May A, Ophoff RA, Terwindt GM, et al. Familial hemiplegic migraine Centro de Estudos de Cefaleias do Serviço de Neurologia do Hospi-
locus on 19p13is involved in the common forms of migraine with and tal Santo António e financiado pela FCT- Fundação para a Ciencia e
without aura. Hum. Genet.,1995;96:604-8. Tecnologia com o número POCTI /34390/MGI/1999. Portugal.

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