Page 11 Volume 20 - N2 - 2012

Dor (2012) 20
32. Maggi CA, Lecci A, Santicioli P, Bianco ED, Giuliani S. Cyclophos- 58. Tominaga M, Numazaki M, Iida T, Tominaga T. [Molecular mecha-
phamide cystitis in rats: involvement of capsaicin-sensitive primary nisms of nociception]. Nihon Shinkei Seishin Yakurigaku Zasshi.
afferents. J Auton Nerv Syst. 1992;38:201-8. 2003;23:139-47. Japonês.
33. Vizzard MA. Alterations in spinal cord Fos protein expression in- 59. Lakshmi S, Joshi PG. Co-activation of P2Y2 receptor and TRPV
duced by bladder stimulation following cystitis. Am J Physiol Regul channel by ATP: implications for ATP induced pain. Cell Mol Neuro-
Integr Comp Physiol. 2000;278:R1027-39. biol. 2005;25:819-32.
34. Dinis P, Charrua A, Avelino A, Cruz F. Intravesical resiniferatoxin 60. Bonnington JK, McNaughton PA. Signalling pathways involved in the
decreases spinal c-fos expression and increases bladder volume to sensitisation of mouse nociceptive neurons by nerve growth factor.
reflex micturition in rats with chronic inflamed urinary bladders. BJU J Physiol. 2003;551:433-46.
Int. 2004;94:153-7. 61. Zhuang ZY, Xu H, Clapham DE, Ji RR. Phosphatidylinositol 3-kinase © Permanyer Portugal 2012
35. Charrua A, Cruz CD, Cruz F, Avelino A. Transient receptor potential activates ERK in primary sensory neurons and mediates inflamma-
vanilloid subfamily 1 is essential for the generation of noxious bladder tory heat hyperalgesia through TRPV1 sensitization. J Neurosci.
input and bladder overactivity in cystitis. J Urol. 2007;177:1537-41. 2004;24:8300-9.
36. Zygmunt PM, Petersson J, Andersson DA, et al. Vanilloid receptors 62. Zhu W, Oxford GS. Phosphoinositide-3-kinase and mitogen activated
on sensory nerves mediate the vasodilator action of anandamide. protein kinase signaling pathways mediate acute NGF sensitization
Nature. 1999;400:452-7. of TRPV1. Mol Cell Neurosci. 2007;34:689-700.
37. Smart D, Gunthorpe MJ, Jerman JC, et al. The endogenous lipid 63. Shin J, Cho H, Hwang SW, et al. Bradykinin-12-lipoxygenase-VR1
anandamide is a full agonist at the human vanilloid receptor (hVR1). signalling pathway for inflammatory hyperalgesia. Proc. Natl Acad
Br J Pharmacol. 2000;129:227-30. Sci USA. 2002;99:10150-5.
38. Huang SM, Bisogno T, Trevisani M, et al. An endogenous capsaicin- 64. Ferreira J, da Silva GL, Calixto JB. Contribution of vanilloid receptors
like substance with high potency at recombinant and native vanilloid to the overt nociception induced by B2 kinin receptor activation in
VR1 receptors. Proc Natl Acad Sci USA. 2002;99:8400-5. mice. Br J Pharmacol. 2004;141:787-94.
39. Chu CJ, Huang SM, De Petrocellis L, et al. N-oleoyldopamine, a 65. Prescott ED, Julius D. A modular PIP2 binding site as a determinant
novel endogenous capsaicin-like lipid that produces hyperalgesia. of capsaicin receptor sensitivity. Science. 2003;300:1284-8.
J Biol Chem. 2003;278:13633-9. 66. Liu B, Zhang C, Qin F. Functional recovery from desensitization of
40. Harrison S, De Petrocellis L, Trevisani M, et al. Capsaicin-like effects vanilloid receptor TRPV1 requires resynthesis of phosphatidylinositol
of N-arachidonoyl-dopamine in the isolated guinea pig bronchi and 4,5-biphosphate. J Neurosci. 2005;25:4835-43.
urinary bladder. Eur J Pharmacol. 2003;475:107-14. 67. Chuang HH, Prescott ED, Kong H, et al. Bradykinin and nerve growth
41. De Petrocellis L, Chu CJ, Moriello AS, Kellner JC, Walker JM, Di factor release the capsaicin receptor from PtdIns(4,5)P2-mediated
Marzo V. Actions of two naturally occurring saturated N-acyldop- inhibition. Nature. 2001;411:957-62.
amines on transient receptor potential vanilloid 1 (TRPV1) channels. 68. Rohacs T, Thyagarajan B, Lukacs V. Phospholipase C mediated
Br J Pharmacol. 2004;143:251-6. modulation of TRPV1 channels. Mol Neurobiol. 2008;37:153-63.
42. Sagar DR, Smith PA, Millns PJ, Smart D, Kendall DA, Chapman V. 69. Stein AT, Ufret-Vincenty CA, Hua L, Santana LF, Gordon SE. Phos-
TRPV1 and CB1 receptor-mediated effects of the endovanilloid/en- phoinositide 3-kinase binds to TRPV1 and mediates NGF-stimulated
docannabinoid N-arachidonoyl-dopamine on primary afferent fibre TRPV1 traffcking to the plasma membrane. J Gen Physiol.
and spinal cord neuronal responses in the rat. Eur J Neuroscience. 2006;128:509-22.
2004;20:175-84. 70. Voets T, Nilius B. Modulation of TRPs by PIPs. J Physiol. 2007;582:939-44.
43. Hwang SW, Cho H, Kwak J, et al. Direct activation of capsaicin re- 71. Lishko PV, Procko E, Jin X, Phels CB, Gaudet R. The ankyrin repeats
ceptors by products of lipoxygenases: endogenous capsaicin-like of TRPV1 bind multiple ligands and modulate channel sensitivity.
substances. Proc Natl Acad Sci USA. 2000;97:6155-60. Neuron. 2007;54:905-18.
44. Jung J, Shin JS, Lee SY, et al. Phosphorylation of vanilloid receptor 72. Liu HT, Kuo HC. Increased expression of transient receptor potential
1 by Ca2+/calmodulin-dependent kinase II regulates its vanilloid vanilloid subfamily 1 in the bladder predicts the response to intra-
binding. J Biol Chem. 2004;279:7048-54. vesical instillations of resiniferatoxin in patients with refractory idio-
45. Amadesi S, Cottrell GS, Divino L, et al. Protease-activated receptor pathic detrusor overactivity. BJU Int. 2007;100:1086-90.
2 sensitizes TRPV1 by protein kinase Cepsilon- and A-dependent 73. Liu L, Mansfield KJ, Kristiana I, Vaux KJ, Millard RJ, Burcher E. The
mechanisms in rats and mice. J Physiol. 2006;575:555-71. molecular basis of urgency: regional difference of vanilloid receptor
46. Ohta T, Ikemi Y, Murakami M, Imagawa T, Otsuguro K, Ito S. Poten- expression in human urinary bladder. Neurouro Urodyn. 2007;26:433-8.
tiation of transient receptor potential V1 functions by the activation 74. Smet PJ, Moore KH, Jonavicius J. Distribution and colocalization of
of metabotropic 5-HT receptors in rat primary sensory neurons. J calcitonin gene related peptide, tachykinins and vasoactive intesti-
Physiol. 2006;576:809-22. nal peptide in normal and idiopathic unstable human urinary blad-
47. Carlton SM, Du J, Zhou S. Group II metabotropic glutamate receptor der. Lab Invest. 1997;77:37-49.
activation on peripheral nociceptors modulates TRPV1 function. 75. Brady CM, Apostolidis AN, Harper M, et al. Parallel changes in blad- Sem o consentimento prévio por escrito do editor, não se pode reproduzir nem fotocopiar nenhuma parte desta publicação.
Brain Res. 2009;1248:86-95. der suburothelial vanilloid receptor TRPV1 and pan-neuronal marker
48. Vetter I, Wyse BD, Monteith GR, Roberts-Thomson SJ, Cabot PJ. The PGP9.5 immunoreactivity in patients with neurogenic detrusor overac-
mu opioid agonist morphine modulates potentiation of capsaicin- tivity after intravesical resiniferatoxin treatment. BJU Int 2004;93:770-6.
evoked TRPV1 responses through a cyclic AMP-dependent protein 76. Lowe EM, Anand P, Terenghi G, Williams-Chestnut RE, Sinicropi DV,
kinase A pathway. Mol Pain. 2006;2:22-37. Osborne JL. Increased nerve growth factor levels in the urinary
49. Vetter I, Cheng W, Peiris M, et al. Rapid, opioid-sensitive mecha- bladder of women with idiopathic sensory urgency and interstitial
nisms involved in transient receptor potential vanilloid 1 sensitiza- cystitis. Br J Urol. 1997;79(4):572-7.
tion. J Biol Chem. 2008; 283:19540-50. 77. Liu HT, Tyagi P, Chancellor MB, Kuo HC. Urinary nerve growth factor
50. Premkumar LS, Ahern GP. Induction of vanilloid receptor channel level is increased in patients with interstitial cystitis/bladder pain
activity by protein kinase C. Nature. 2000;408:985-90. syndrome and decreased in responders to treatment. BJU Int.
51. Vellani V, Mapplebeck S, Moriondo A, Davis JB, McNaughton PA. 2009;104:1476-81.
Protein kinase C activation potentiates gating of the vanilloid recep- 78. Xue Q, Jong B, Chen T, Schumacher MA. Transcription of rat TRPV1
tor VR1 by capsaicin, protons, heat and anandamide. J Physiol. utilizes a dual promoter system that is positively regulated by nerve
2001;534:813-25. growth factor. J Neurochem. 2007;101:212-22.
52. Sugiura T, Tominaga M, Katsuya H, Mizumura K. Bradykinin lowers 79. Charrua A, Reguenga C, Paule CC, Nagy I, Cruz F, Avelino A. Cys-
the threshold temperature for heat activation of vanilloid receptor 1. titis is associated with TRPV1b-downregulation in rat dorsal root
J Neurophysiol. 2002;88:544-8. ganglia. Neuroreport. 2008;19:1469-72.
53. Carr MJ, Lollarik M, Meeker SN, Undem BJ. A role for TRPV1 in 80. Charrua A, Reguenga C, Cordeiro JM, et al. Functional transient
bradykinin-induced excitation of vagal airway afferent nerve termi- receptor potential vanilloid 1 is expressed in human urothelial cells.
nals. J Pharmacol Exp Ther. 2003;304:1275-9. J Urol. 2009;182:2944-50.
54. Tang HB, Inoue A, Oshita K, Nakata Y. Sensitization of vanilloid re- 81. Wang C, Hu HZ, Colton CK, Wood JD, Zhu MX. An alternative splic-
ceptor 1 induced by bradykinin via the activation of second mes- ing product of the murine trpv1 gene dominant negatively modulates
senger signaling cascades in rat primary afferent neurons. Eur J the activity of TRPV1 channels. JBC. 2004;279:37423-30.
Pharmacol. 2004;498:37-43. 82. Vos MH, Neelands TR, McDonald HA, et al. TRPV1b overexpression
55. Mizumura K, Sugiur T, Koda H, et al. [Pain and bradykinin receptors- negatively regulates TRPV1 responsiveness to capsaicin, heat and
sensory transduction mechanism in the nociceptor terminals and low pH in HEK293 cells. J Neurochem. 2006;99:1088-102.
expression change of bradykinin receptors in inflamed condition]. 83. Eilers H, Lee SY, Hau CW, Logvinova A, Schumacher MA. The rat
Nihon Shinkei Seishin Yakurigaku Zasshi. 2005;25:33-8. Japonês. vanilloid receptor splice variant VR.5’sv blocks TRPV1 activation.
56. Tominaga M, Wada M, Masu M. Potentiation of capsaicin receptor Neuroreport. 2007;18:969-73.
activity by metabotropic ATP receptors as a possible mechanism for 84. Schumacher MA, Moff I, Sudanagunta SP, Levine JD. Molecular
ATP-evoked pain and hyperalgesia. PNAS USA. 2001;98:6951-6. cloning of an N-terminal splice variant of the capsaicin receptor.
DOR 57. Moriyama T, Iida T, Kobayashi K, et al. Possible involvement of P2Y2 85. Xue Q, Yu Y, Trilk SL, Jong BE, Schumacher MA. The genomic or-
JBC. 2000;275:2756-62.
metabotropic receptors in ATP-induced transient receptor potential
10 vanilloid receptor 1-mediated thermal hypersensitivity. J Neurosci. ganization of the gene encoding the vanilloid receptor: evidence for
multiple splice variants. Genomics. 2001;76:14-20.
2003;23:6058-62.